Januvia is a pill that is given to adults with type 2 diabetes mellitus. It is administered only once per day and works alongside diet and exercise regimes to reduce blood sugar levels. This medicine can be combined with other diabetes drugs.
Each tablet of Januvia contains sitagliptin phosphate monohydrate which is the active ingredient. Other inactive ingredients include anhydrous dibasic calcium phosphate,
Sodium stearyl fumarate, microcrystalline cellulose, magnesium stearate, croscarmellose sodium, titanium dioxide, yellow iron oxide, red iron oxide, polyvinyl alcohol, talc, and polyethylene glycol.
- Pharmacological Action
When your blood sugar level is high, Januvia helps to regulate it. On the other hand, when your blood sugar is low, Januvia doesn’t do much. Sitagliptin works by boosting the level of incretins, which are naturally occurring substances in the body whose role is to regulate blood sugar levels. This is achieved by increasing the amount of insulin released particularly after you have eaten food. Additionally, this pill helps to reduce the amount of sugar your liver produces.
Januvia is indicated for controlling high blood sugar for diabetes type 2 patients. Keeping blood levels in check helps to prevent kidney damage, nerve complications, loss of limbs, blindness and boosts sexual functions. Controlling blood sugar levels helps to lower the risk of getting a stroke or heart attack.
- Mode of Indication, Dosage, and Treatment Duration
Januvia tablets are available in 25 mg, 50 mg, and 100 mg dosage strengths. The standard recommended dose is 100 mg once per day. This pill is taken orally with or without food. However, your doctor will prescribe a dose based on your medical state, the state of your kidney and how you respond to treatment. Maximum benefit is obtained when this medication is taken regularly preferably at the same time each day. It’s important to follow the medication plan, meal plan, and exercise program that the doctor recommends.
Keep in mind your doctor might recommend other drugs to take together with Januvia, or change your medication depending on how you respond. During medication, your blood sugar levels need to be regularly monitored. Two doses of sitagliptin should never be taken at the same time. It can take any time from a week or longer to begin seeing the effects of this medication.
- Januvia Side Effects
Side effects of Januvia include:
- Sore throat;
- Stomach pain;
- Runny or stuffy nose;
- Joint or muscle pain;
- Back pain.
Before commencing Januvia medication, you should let the doctor know if you’re allergic to sitagliptin. Side effects of an allergic reaction include a swollen face, tongue and lips, hives, rash and swallowing, and breathing difficulties. When these side effects manifest, you should suspend taking this medication and seek immediate medical attention.
Let the doctor know if you have these conditions:
- Blurred vision;
- Heart failure;
- Kidney disease;
- Stress-related conditions;
- Pregnancy or intention to become pregnant as the doctor may need to adjust your dosage if you’re expectant;
- Breastfeeding as it is unknown whether Januvia is passed into breastmilk.
Due to the effects of dizziness and drowsiness, you shouldn’t operate a machine or drive after taking Januvia. In addition, alcohol use should be limited because it can cause low blood sugar.
- Drug Interaction
Januvia can interact with different kinds of drugs which can either increase or reduce its effectiveness. Let the doctor know if you’re currently taking or have recently been on the following medications:
- Non-steroidal anti-inflammatory drugs (NSAIDs);
- Sulfa drugs;
- Monoamine oxidase inhibitors (MAOIs);
- Aspirin/other salicylates.
You should let the doctor know about all prescription, non-prescription, and herbal products you are using.